Synthesis and Spectroscopic Characterizations of Some Essential Metal Ion (MgII, CaII, ZnII, and FeIII) Pipemidic Acid Chemotherapeutic Agent Complexes

The assignments structures of the four 1:1 pipemidic acid (pipH)–magnesium(II), calcium(II), zinc(II), and iron(III) complexes, [Mg(pip)(H2O)3(Cl)].6H2O, [Ca(pip)(H2O)3(Cl)].2H2O, [Zn(pip)(H2O)3(Cl)].4H2O, [Fe(pip)(H2O)2(Cl)2].6H2O, (where pip = deprotonated pipemidic), were synthesized through chemical reactions MgCl2.6H2O, CaCl2.2H2O, ZnCl2, FeCl3.6H2O metal salt chlorides with pipH chemotherapeutic agent ligand in a methanolic solvent. microanalytical analysis CHN, conductance, (infrared (FTIR) electronic (UV–Vis.)) spectra, thermogravimetric measurements (TG) have been utilized to discuss solid isolated complexes. X-ray powder diffraction (XRD) transmission electron microscopy (TEM) confirm nanostructured form is coordinated Mg(II), Ca(II), Zn(II), Fe(III) ions two oxygen atoms carbonyl (quinolone group) carboxylic group. thermodynamic parameters (energy, E*), (entropy, ΔS*), (enthalpy, ΔH*), (Gibbs free energy, ΔG*) activation estimated based on curves using “Coats–Redfern Horowitz–Metzeger non–isothermal” methods.